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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f5253646bfd1457ed1c54f2e4615b480b683094da91dfbc32dcdd1f553084611' 
  AND token = '8jIMC1TcC+T8BKDclyUk5EpBTcY3hJ0saiGC7hncsc8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}