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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78b0b48a996ba45ca8249092c39875bbc6753a44ce767949787d3f9c51ab0e7d' 
  AND token = 'dtxa14kr6ZOZdbmqxOgcSXLgfTUCtw7pvrMZm722AGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}