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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c99267d39acdb2d936955a3bb03ed771e425f8d3050ff6e5cd9ea5bf12ee780' 
  AND token = '0IKTZFhpYY+kCBN7onyEmT00MDn6DxPTKZiBle1ViQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}