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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de6a37eb045ecbb525b2928728dc422bea1e80f1e690d34d07afc5d64c625209' 
  AND token = 'LLTW6iODsT4zrVaXlDrVu5zVE7gbSPFT610VmKmCQeU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}