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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af9d863e08719f6257619d6580d2ad2555e7e7f667062010a4ff98fe551ef8f0' 
  AND token = 'csVN4MMyT5mpU+uj23GuYseIjFgW/RkkFlLNk/xM3Gs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}