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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49a67d9f88cf4b7143f134c38b3e8f5c0636acbada2632c6d7eed745fde75e18' 
  AND token = 'gbdElPszFaKr8/7rFoLUFfpWVCjM00h3Z5HiuUMsVMQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}