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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8c01b0ae683188b5c40f495119026b42445b11dddfbfa87308723c76a7f3825' 
  AND token = 'IiedqDQb/Jc1YnsYcjuAnSI40bT+aIMbrtn+cA5B1NY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}