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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '121cb99166891e12fb5dfc6a7b1a19bb10b96060b029fdebfbf00a15defc1450' 
  AND token = 'C1nsf+t33jmTE89N0fUan0OnV7vAp3EvSx1dOo7qHqA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}