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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c21d75cefea8c4855a22820a6625583bdeabf52cb50dc96d81f56e827b5730d' 
  AND token = '0Z16pX2Pc6TeK6a/sdAz/1Kwbcg/BcSrq9XypMwOYXo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}