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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e44b3714f69f97f3a9d27ce530f2db61dd4a25602e78653ac10481a9d5e978e3' 
  AND token = 'CWDPMTbkRGYpbAU4zG+c6n8diT5hiu5u1a8TuZ9tJPg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}