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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e52447aa9bc04e379ccd2874cafc5689de9a9b1fff35c5faa22c0f3496e1602' 
  AND token = 'IZ08ewjkgATDSXqF4SvcKQ+bJpco4AG3ZLPFFk05Tyw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}