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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6422b95d546ac9b885c4993e980e0c8c948e6d4e4d0ee144112332770d59c776' 
  AND token = '2mb62DjHF5av6nOn+uw9Q2hJI/yTtXrGfMqIS4qi6aQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}