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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b289c896f57ab2bc5f5b11bbb7c4761b774f3b6d2357a19c5f157bc353e980' 
  AND token = 'ydRUA2IQRX8D8iZQdQUm9J8t7WysgGj4QES+DXv0EyY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}