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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22dc7bc96c4d97cb412578e5b81b013dec8e348cd607fc8c94380bef7196efcf' 
  AND token = 'nLKyJ1u9iQqqM0J9xbiwFgDuWgHoR+ubjcfwncMGpX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}