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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10d845fb64d64f84c2131e9bc093a974a54bdd557cbecf49208cbb22fa1d5ec7' 
  AND token = 'b+S5/1dy+/MgtLNTv5Pi2FlHg6nILLqbYTUjgXC7TUw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}