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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4293100e629a881e01ce0c5afe03f85a9426f956f63c6865267c009596f82971' 
  AND token = 'db02ewEx9MAM+igu+TMrvmjqZ8dPRnXoky+vzhvK/eY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}