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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '273dfd37d4ae52823b1bd6d9a4ff41f3aa14fce284d3483d56da56e821718512' 
  AND token = 'o+0B2DDzTBbJHDoByyEHjNNsmUpqh3+n7oMmmjmPl9U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}