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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '67e0291b54dc7f925dd826d980a41ec59b4fbc38b07437f7e43b53e8af49461a' 
  AND token = 'r45Q1PPSEcX+A4po/pPS5yPaMg+vX/ffyNIJ1JXcP5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}