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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0346a6282ecc223b446f15a733bcf020602dbac35bc67e0b72bdb6608075a8e8' 
  AND token = '06TEeO0DfcLy/ol7u66ed0ovBFh1IRzrtW+rbLQuceY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}