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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222b55e4c097767d2d2adf0b4b181edcd10e48a2208d1db5c34eee380e01a412' 
  AND token = 'uA7+AnaznNT0o1tFZGj4vsnO7/8Zo2dIEo1Z10tTlj0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}