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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c5db775fef2f1707e02065f0ab199a3459ab41f20b3a3c2b95d2483952903c2' 
  AND token = '+V0KQWCm0h5KlIpnLERFR+wMfHG2A01Gl6xXAgNS/IE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}