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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45fe731b3e8661334483885824f1a8fe6d8dce1ff7ee1e94581d9cbb0a0c9b20' 
  AND token = '271dKqlTONO4NZKFFjaSqWgtaQt9Kk1hT12QAktIc8E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}