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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2288cbd3b8bf80b635db33a9d1dc9dd26853aa9d65993444e9d48708ee8e1646' 
  AND token = 'e3ShhP6+g150F1poEX0jQxFXvxh+Dc2Ndq6g6f1gZDk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}