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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c3e80980149eaf43a66d971b9458b75b0ea753d520e3bd26fc9855c7024412' 
  AND token = 'nAS78Q9W7iiuEapIpkxSrAAgeahouU8Mdwmp1SyoUpk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}