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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e0805a1d22e093c9a1b24a6f06b2fd7368dcaed441685ab36d59e8077ed041' 
  AND token = 'IxfHzM5lnFdjB6Icqa6o8LyrNuAeDEGDggFznunNWIA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}