SELECT 
  data, 
  expiry 
FROM 
  cscart_cache 
WHERE 
  name = 'schemas.cache_customerschema_block_manager_blocks' 
  AND company_id = 0 
  AND (
    expiry = 0 
    OR expiry > 1781872988
  )

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "1.00"
    },
    "table": {
      "table_name": "cscart_cache",
      "access_type": "const",
      "possible_keys": [
        "PRIMARY",
        "name",
        "company_id"
      ],
      "key": "PRIMARY",
      "used_key_parts": [
        "name",
        "company_id"
      ],
      "key_length": "771",
      "ref": [
        "const",
        "const"
      ],
      "rows_examined_per_scan": 1,
      "rows_produced_per_join": 1,
      "filtered": "100.00",
      "cost_info": {
        "read_cost": "0.00",
        "eval_cost": "0.20",
        "prefix_cost": "0.00",
        "data_read_per_join": "1K"
      },
      "used_columns": [
        "name",
        "company_id",
        "data",
        "expiry"
      ]
    }
  }
}