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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e7bacdf7c1db19585cd5c2d076e81f35cf598d7fb0189587b0d1ab20dc03c1' 
  AND token = 'CIZERNSzwTFX3HhcqOIHN/Ez5uDwFZh936Ad0uKX83I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}