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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1212f5a4201b13c73bce48e23242eea0292c6663885ec0441006e20b78696bff' 
  AND token = 'trDp4Ct8eiT9XRzNZ5RPRLDMUqOq++yp7pw5PbAQpLI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}