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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c6ebfe023941c9f4555a827ef85631d01e663536b6fe696ba15e14b6658e15' 
  AND token = 'SAEcmey43i43laHgbh2I2r+FddOLtuyrT+fzqPteni0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}