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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ae4a80f6945842757e913a85430d3c23882fa71f55fdf43900b80d1cb38c743' 
  AND token = 'JdLUvjmhCnbOemKqTTJr6KFIQy/49nlhlTNr7FC8Xt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}