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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42fc21eb73149621a989816e693617a2bdb22bfe2eda22abf0daad28e90f584e' 
  AND token = 'UPOYQtsb5N2iLIXab4Dc9Lg4ygTbitC63SL3qf0d2tY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}