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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a800a4ef192d917d38519a0121b28f89f7412e13750ea1af9f6a0a9536a93354' 
  AND token = 'DEP0ZBFAyRad0/+tx6rqc34lqwNMppRqFBnqWIniOoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}