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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7ea5b43916f315893ff13f3b1b0bf74b9097229ec1ee825b4cecdabc5b4c9b09' 
  AND token = 'Iys+UC+N4zV7Pspkm1bFv+VoNptwVcbHI0IZU37ifbA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}