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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80ae07a05d7290ee51d646273a8dc71678d2bd1b9d4a2fce7f0ed44c27d96c61' 
  AND token = 'zYupVTVJZBVlLjmWfUSHXjsUAtOA32S5g9k6BK5+0t0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}