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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80377bf36ce537081b38de39adf26ab138210ff81bfdd31d2a680c8bc1f500f3' 
  AND token = 'LpA5QywMkh3fgOYTfo0bhd3AFUMv4/g14kp4aEgIMJ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}