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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '501b2e3d0ffe3995a136416cb473b21c470b265e68713b4a656487ee28eb080b' 
  AND token = 'MY/VtmRYkeLS4NHGGy0Svez1MxMT5flEFj0ZJhZIPes=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}