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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ac165b2e560e42888a7ef2320d7c49bf69bfb3a157e8a80145d167aadb481d29' 
  AND token = 'di5B2xDUXTUl3hu4a7IUPXMZYh8WYbcRTPI41aZK5gU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}