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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7388fdaa1c1718b49fa5114e432b2bb9f97a7809aa4913f7714e8ba9d0085811' 
  AND token = 'Vqz+rYHFs3mLD83dyDdWfRQHQ+/uAoQ2zdaDb2M0/5o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}