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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9f5e913c05a7827b91fd70b61e37da395a7716e087c5549b2a7be6ae6069c1e9' 
  AND token = 'TIwM2Q1PnQJ/xpuRmtlpG5YZ4vonAS/xITpj1so8Xgc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}