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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '290d905da0dbb13a6d539a4b00fa96b7be95508342e19b679b0e707b950b38bd' 
  AND token = 'R2Hs506SNxc4LWiPEfuxPs4VG+e5mlcpmM7qY8gwIyY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}