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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b4e302a56205dc18a4dfda97cc0533f29ae5419cbdf30208400f3bac7ea9b81' 
  AND token = '/VoKi1aAQQ02cSrDrPBhjkRM+ueI9M6hrcIq6SUiJmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}