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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '266b2aebeea613a56e9ea456d03a7f041d86cbea9ec55745f2a0608a78de9800' 
  AND token = '2bHtwtpmBIt5mDpt+VN+FhjWKzkk9Cq95B8N77XC/Vs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}